Weather and climate models are required to calculate radiative fluxes and shortwave heating and longwave cooling rate profiles on a large scale. Heating and cooling rates describe the effect that different configurations of temperature, radiatively active gases, and clouds have on the rates of interlayer energy exchange and affect circulation patterns. Meanwhile, a suite of satellite-based instruments from the NASA Earth Observing System’s A-Train provide an unprecedented set of measurements that can be used to produce quantities that can also yield radiative fluxes and heating and cooling rates. This work explores the extent to which passive-infrared hyperspectral measurements such as those made by the Atmospheric Infrared Sounder impart information towards infrared cooling rates. Several novel methods are explored for interpreting and retrieving cooling rates using spectral measurements.