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Ebook Effects of weight loss after bariatric surgery for morbid obesity on vascular endothelial growth factor-A, adipocytokines and insulin.
Submitted by wulan on Mon, 09/14/2009 - 01:26Growth of any tissue requires the formation of a functional and mature vasculature. Adipose tissue, unlikeother organs, grows and develops continuously throughout life. In vitro studies showed that differentiating adipocytes and adipose tissue explants trigger blood vessel formation and that in turn adipose tissue endothelial cells promote preadipocyte differentiation. Furthermore, adipose tissue growth in mice can be impaired with angiogenesis inhibitors or inactivation of proangiogenic factors.
Vascular endothelial growth factor-A (VEGF-A) plays a pivotal role in both physiological and pathological angiogenesis through the increase of proliferation and migration of endothelial cells and permeabilization of blood vessels by inducing fenestrations in the endothelium. VEGF-A is highly expressed in adipose tissue and its expression increases significantly during adipocyte differentiation in several experimental models. This close relationship between adipogenesis and VEGF-A induced angiogenesis has been demonstrated in in vitro and in in vivo studies. The inhibition of angiogenesis by VEGF receptor-2 blocking antibodies not only reduced angiogenesis but also inhibited murine adipose cell differentiation.
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Ebook Mcdo: The Socio Cultural Impact Of Fast Food On Parisian Dining Habits And Pop Culture
Submitted by wulan on Wed, 08/19/2009 - 01:42Since the beginning of time, France has defined the culinary arts for gourmets around the world. Indisputably its capital, Paris, today reigns as the Mecca for lovers of “haute cuisine” or “fine dining” worldwide. Be that as it may, over the past two decades a new phenomenon has taken the city of lights by storm. Names such as “McDonald’s”, “Quick”, and “KFC” have literally invaded Paris and have become staples in the daily lives of Parisians. This, however, did not come easy. Along with a tradition of culinary arts is also a culture deeply entrenched in its sense of history and place in society. As expected, this traditionalistic society has been resistant to change, particularly to the winds of “Americanization” and “Globalization.” For many French people there is an association that good food is French and fast food is American and bad, said Michel Crozier, a leading French sociologist (Greenhouse 14).
Traditionally considered an aberration by the French, and by default Parisian standards, fast food has represented, at least for Americans, the practical solution to the emerging problem of two income families and latchkey kids. This does come at a price. One example in the US is the recent legal processes that have been opened against mega fast food chain McDonald’s under allegations that their products have significantly contributed to obesity in children. McDonald’s has denied the allegations and until today has successfully dismissed the suits in court.
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Ebook The prevention of overweight and obesity in children and adolescents: a review of interventions and programmes
Submitted by puput on Mon, 12/14/2009 - 02:56During the past two decades the prevalence of overweight and obesity in children has increased rapidly worldwide (1–5). These trends have been associated with various changes in the social, economic and physical environment related to the nutrition transition (6). The nutrition transition is generally associated with an increase in the consumption of energy dense foods that are low in fibre, sugar, and sweetened drinks, a decrease in physical activity and a more sedentary lifestyle. Thus, overweight and obesity have become serious, large scale, global, public health concerns (7, 8). The obesity epidemic has been associated with a dramatic increase in related healthcare costs, for example in the USA a more than a threefold increase between 1979 and 1981 and 1997–1999 was observed (9).
Childhood obesity, itself, is associated with a wide range of serious medical complications. Early medical consequences of obesity include orthopaedic complications, metabolic disturbances, type 2 diabetes, disrupted sleep patterns, poor immune function, skin problems, impaired mobility, and increased blood pressure and hypertension (10). Childhood obesity has an immediate impact on a child’s physical appearance and can result in additional psycho-social consequences, such as a low self-esteem, social alienation, and lack of self-confidence (10, 11), discrimination (12) and, for girls, depression (13). Additional long-term health risks are partly related to the tracking of childhood obesity into adulthood. Long-term follow-up studies show that obese children tend to become obese adults (14–16). Related to the continuity of obesity into adulthood are long-term consequences of childhood obesity such as increased risk of cardiovascular disease, insulin resistance, type 2 diabetes, hyperlipidaemia, gall bladder disease, osteoarthritis and certain cancers (11). Moreover, adults who were obese children have an increased risk on morbidity and mortality independent of their adult weight (11). Obese children are more vulnerable to orthopaedic abnormalities related to damage to an unfused growth plate, slipped capital epiphyses, bowing of the legs and tibial tortion, sleep disorders, and insulin resistance has been noted even in children below 10 years (11).
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